KT is a 60 yo woman with GERD and LA Grade B esophagitis who has been on lansoprazole 30 mg PO BID for 15 years. Her friend recently told her that it was not good to take PPIs long-term, and she wants to know what risks she should be aware of. Which of the following is the best counseling point regarding risks associated with long-term PPI use? KT is a 60 yo woman with GERD and LA Grade B esophagitis who has been on lansoprazole 30 mg PO BID for 15 years. Her friend recently told her that it was not good to take PPIs long-term, and she wants to know what risks she should be aware of. Which of the following is the best counseling point regarding risks associated with long-term PPI use? Hypermagnesemia is rare, but can occur and is life-threatening There are no long-term risks associated with PPI use There is a risk of bone fractures that is most significant in those with other risk factors for fractures, including osteoporosis