Pharmaceutics Exam 3 Study 1. Be familiar the categories of Compounded Sterile Preparations (CSPs) described in USP 2. Which is “cleaner” – ISO Class 5 air or ISO Class 8 air? (do not need to memorize particles per cubic meter) 3. What are anterooms and buffer rooms? 4. What is a PEC? What air quality must a PEC meet? 5. What is the difference between Quality Assurance (QA) and Quality Control (QC)? 6. Why is room pressure important in a sterile compounding suite? 7. What is the most prevalent mode of drug absorption? 8. Symport and Antiport transport are modes of which type of active transport? 9. Be familiar with the structure of the GI tract (pH, relative surface area, permeability) 10. What structures of the small intestine provides for such a high surface area 11. What are the factors that drive passive diffusion? 12. What is the nature of drug transporters? Where are they found? What types of molecules are they? 13. What is the difference between facilitated diffusion vs active transport? 14. What is the difference between Influx and Efflux? 15. What is the difference between competitive and non-competitive inhibition? 16. How can es grapefruit juice affect bioavailability? 17. Why are solid oral dosage forms so popular? 18. What is the difference between immediate release and modified release? 19. What is a compressed tablet? 20. What materials are 2-piece hard shell capsules made from? 21. What are typical sizes of hard shell capsules (i.e. size 000 to size 5)? How do they differ? 22. What is a chart? 23. What are the 6 types of excipients that are typically used in an immediate release tablet? 24. Be able to differentiate between a weak acid and a weak base on a solubility vs pH graph 25. What is hygroscopicity? 26. What is the difference between delayed and extended release? 27. How can drug release be controlled? With an immediate release dosage form, what is the rate limiting step in plasma levels vs an extended release dosage form? 28. What is the healthy pH of saliva? 29. What is the difference between transcellular and paracellular drug transport? 30. What are the advantages of the oral transmucosal route of administration? 31. Benefits of inhalation drug delivery? 32. What are the three types of dosage forms for inhalation delivery? 33. What airway generations in the respiratory system are responsible for air conduction? Which are responsible for solute exchange? 34. What is the largest particle size that can be delivered to the last 5-6 generations of the lung? What size is likely to be exhaled due to breathing? 35. To treat local asthma conditions, drug particles/droplets should be deposited where in the respiratory system? Where should particles /droplets be deposited for systemic absorption? 36. What are the formulation components of pMDIs? 37. What is the excipient in a DPI formulation? Why is it used? What is the most common excipient? 38. How does a nebulizer differ from a pMDI and DPI? How are aerosol droplets created in a nebulizer (2 types)? 39. What are the advantages of a nebulizer? What are the disadvantages?